MUSCLE (3.7) multiple sequence alignment NC_002645_HCoV-229E_inf-1_nsp10_ -AGKQTEFVSNSHLLTHCSFAVDPAAAYLDAVKQGAKPVGNCVKMLTNGSGSGQAITCTI NC_005831_HCoV-NL63_AmsterdamI_n -AGKQTELAVNSGLLTACAFSVDPATTYLEAVKHGAKPVSNCIKMLSNGAGNGQAITTSV NC_002306_TGEV_PUR46-MAD_nsp10_1 -AGKPTEHPSNSSLLTLCAFSPDPAKAYVDAVKRGMQPVNNCVKMLSNGAGNGMAVTNGV NC_003436_PEDV_CV777_nsp10_12192 -AGKQTEQAINSSLLTLCAFAVDPAKTYIDAVKSGHKPVGNCVKMLANGSGNGQAVTNGV DQ811787_PRCV_ISU-1_nsp10_11884. -AGKPTEHPSNSSLLTLCAFAPDPAKAYVDAVKRGMQPVNNCVKMLSNGAGNGMAVTNGV AY994055_FIPV_79-1146_nsp10_1197 -AGKPTEHPSNSGLLTLCAFAPDPAKAYVDAVKRGMQPVTNCVKMLSNGAGNGMAITNGV NC_009657_BtCoV-G1_BtCoV/512/200 -AGKQTEQATNSSLLTLCAFAVDPPKTYLDAVKSGHRPVGNCVKMLANGSGNGQAITNGV EF203064_Bat-CoV-HKU2_HKU2/GD/43 -AGKQTELACNSSLLTLCAFAVDPAKAYVSAVKQGAKPVGNCVKMLANGSGSGQAVTNGV NC_005147_HCoV-OC43_OC43_nsp10_1 -AGTATEYASNSSILSLCAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKP NC_006577_CoV-HKU1A_N1_nsp10_131 -AGVATEYAANSSILSLCAFSVDPKKTYLDYIQQGGVPIINCVKMLCDHAGTGMAITIKP AY884001_CoV-HKU1B_N2_nsp10_1307 -AGVATEYAANSSILSLCAFSVDPKKTYLDYIQQGGVPIINCVKMLCDHAGTGMAITIKP DQ339101_CoV-HKU1C_N5_nsp10_1301 -AGVATEYAANSSILSLCAFSVDPKKTYLDYIQQGGVPIINCVKMLCDHAGTGMAITIKP NC_003045_BCoV_BCoV-ENT_nsp10_12 -AGTATEYASNSSILSLCAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKP NC_001846_MHV_MHV-A59_nsp10_1316 -AGTATEYASNSAILSLCAFSVDPKKTYLDYIKQGGVPVTNCVKMLCDHAGTGMAITIKP NC_007732_PHEV_VW572_nsp10_12907 -AGTATEYASNSSILSLCAFSVDPKKTYLDFIQQGGTPIVNCVKMLCDHAGTGMAITAKP EF424621_AntelopeCoV_US/OH1/2003 -AGTATEYASNSSILSLCAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKP EF424622_GiCoV_US/OH3-TC/2006_ns -AGTATEYASNSSILSLCAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKP NC_004718_SARS-human_Tor2_nsp10_ -AGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTP AY304488_SARS-civet_SZ16_nsp10_1 -AGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTP NC_009694_SARS-bat_HKU3-1_nsp10_ -AGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTP AY545919_SARS-badger_CFB/SZ/94/0 -AGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTP NC_009019_Bat-CoV-HKU4_B04f -AGANTEFASNSTVLTLVAFAVDPAKAYLDYVGSGGTPLSNYVKMLAPKTGTGVAISVKP NC_009020_Bat-CoV-HKU5_LMH3f -AGSNTEFAINSSVLSAVTFSVDPGKAYLDFVNAGGAPLTNCVKMLTPKTGTGIAVSVKP NC_009021_Bat-CoV-HKU9_BF_005I -AGSATEVASNSSILSLCSFSVDPEATYKDYLDNGGSPIGNCVKMLTPHTGTGLAITAKP NC_001451_IBV_Beaudette_nsp10_11 SKGHETEEVDAVGILSLCSFAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKP AY646283_IBV-partridge_Partridge SKGYETEEVDSVGILSLCSFAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKP AY641576_IBV-peafowl_Peafowl/GD/ SKGHETEEVDAVGILSLCSFAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKP * ** :*: :*: ** :* . : * *: * :*** *.* *:: NC_002645_HCoV-229E_inf-1_nsp10_ DSNTTQDTYGGASVCIYCRAHVAHP----TMDGFCQYKGKWVQVPI-GTNDPIRFCLENT NC_005831_HCoV-NL63_AmsterdamI_n DANTNQDSYGGASICLYCRAHVPHP----SMDGYCKFKGKCVQVPI-GCLDPIRFCLENN NC_002306_TGEV_PUR46-MAD_nsp10_1 EANTQQDSYGGASVCIYCRCHVEHP----AIDGLCRYKGKFVQIPT-GTQDPIRFCIENE NC_003436_PEDV_CV777_nsp10_12192 EASTNQDSYGGASVCLYCRAHVEHP----SMDGFCRLKGKYVQVPL-GTVDPIRFVLEND DQ811787_PRCV_ISU-1_nsp10_11884. EANTQQDSYGGASVCIYCRCHVEHP----AIDGLCRYKGKFVQIPT-GTQDPIRFCIENE AY994055_FIPV_79-1146_nsp10_1197 ESNTQQDSYGGASVCIYCRCHVEHP----AIDGLCRFKGKFVQVPT-GTQDPIRFCIENE NC_009657_BtCoV-G1_BtCoV/512/200 EASTNQDSYGGASVCLYCRAHVEHP----DMDGFCKLRGKYVQVPL-GTLDPIRFVLENT EF203064_Bat-CoV-HKU2_HKU2/GD/43 EANMNQDSYGGASVCIYCRAHVDHP----AMDGACRFKGKYVQIPI-GVNDPIRFCIENE NC_005147_HCoV-OC43_OC43_nsp10_1 DATTSQDSYGGASVCIYCRARVEHP----DVDGLCKLRGKFVQVPV-GIKDPVSYVLTHD NC_006577_CoV-HKU1A_N1_nsp10_131 EATINQDSYGGASVCIYCRARVEHP----DVDGICKLRGKFVQVPL-GIKDPILYVLTHD AY884001_CoV-HKU1B_N2_nsp10_1307 EATINQDSYGGASVCIYCRARVEHP----DVDGLCKLRGKFVQVPL-GIKDPILYVLTHD DQ339101_CoV-HKU1C_N5_nsp10_1301 EATINQDSYGGASVCIYCRARVEHP----DVDGICKLRGKFVQVPL-GIKDPILYVLTHD NC_003045_BCoV_BCoV-ENT_nsp10_12 DATTNQDSYGGASVCIYCRARVEHP----DVDGLCKLRGKFVQVPV-GIKDPVSYVLTHD NC_001846_MHV_MHV-A59_nsp10_1316 EATTNQDSYGGASVCIYCRSRVEHP----DVDGLCKLRGKFVQVPL-GIKDPVSYVLTHD NC_007732_PHEV_VW572_nsp10_12907 DATTSQDSYGGASVCIYCRARVEHP----DVDGLCKLRGRFVQVPV-GIKDPVSYVLTHD EF424621_AntelopeCoV_US/OH1/2003 DATTNQDSYGGASVCIYCRARVEHP----DVDGLCKLRGKFVQVPV-GIKDPVSYVLTHD EF424622_GiCoV_US/OH3-TC/2006_ns DATTNQDSYGGASVCIYCRARVEHP----DVDGLCKLRGKFVQVPV-GIKDPVSYVLTHD NC_004718_SARS-human_Tor2_nsp10_ EANMDQESFGGASCCLYCRCHIDHP----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNT AY304488_SARS-civet_SZ16_nsp10_1 EANMDQESFGGASCCLYCRCHIDHP----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNT NC_009694_SARS-bat_HKU3-1_nsp10_ EANMDQESFGGASCCLYCRCHIDHP----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNT AY545919_SARS-badger_CFB/SZ/94/0 EANMDQESFGGASCCLYCRCHIDHP----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNT NC_009019_Bat-CoV-HKU4_B04f EATADQETYGGASVCLYCRAHIEHP----DVSGVCKYKTRFVQIPA-HVRDPVGFLLKNV NC_009020_Bat-CoV-HKU5_LMH3f EANADQDTYGGASVCLYCRAHIEHP----DVTGVCKFKGKFVQVPL-HIRDPVGFCLQNT NC_009021_Bat-CoV-HKU9_BF_005I DANIDQESFGGASCCLYCRCHIEHP----GASGVCKYKGKFVQIPLVGVNDPIGFCIRNV NC_001451_IBV_Beaudette_nsp10_11 SPTPDQDSYGGASVCLYCRAHIAHPGSVGNLDGRCQFKGSFVQIPT-TEKDPVGFCLRNK AY646283_IBV-partridge_Partridge SPTPDQDSYGGASVCLYCRAHIAHPGSAGNLDGRCQFKGSFVQIPT-TEKDPVGFCLRNK AY641576_IBV-peafowl_Peafowl/GD/ SPTPDQDSYGGASVCLYCRAHIAHPGGAGNLDGRCQFKGSFVQIPT-TEKDPVGFCLRNK ... *:::**** *:***..: ** * * . **:* **: : : : NC_002645_HCoV-229E_inf-1_nsp10_ VCKVCGCWLNHGCTCDRT-----AIQ NC_005831_HCoV-NL63_AmsterdamI_n VCNVCGCWLGHGCACDRT-----TIQ NC_002306_TGEV_PUR46-MAD_nsp10_1 VCVVCGCWLNNGCMCDRT-----SMQ NC_003436_PEDV_CV777_nsp10_12192 VCKVCGCWLSNGCTCDRS-----IMQ DQ811787_PRCV_ISU-1_nsp10_11884. VCVVCGCWLNNGCMCDRT-----SMQ AY994055_FIPV_79-1146_nsp10_1197 VCVVCGCWLTNGCMCDRT-----SIQ NC_009657_BtCoV-G1_BtCoV/512/200 VCKVCGCWQANGCTCDRA-----VIQ EF203064_Bat-CoV-HKU2_HKU2/GD/43 VCKVCGCWLNNGCSCDRS-----SVQ NC_005147_HCoV-OC43_OC43_nsp10_1 VCRVCGFWRDGSCSCVSTDT---TVQ NC_006577_CoV-HKU1A_N1_nsp10_131 VCQVCGFWRDGSCSCVGSSV---AVQ AY884001_CoV-HKU1B_N2_nsp10_1307 VCQVCGFWRDGSCSCVGSGV---AVQ DQ339101_CoV-HKU1C_N5_nsp10_1301 VCQVCGFWRDGSCSCVGSSV---AVQ NC_003045_BCoV_BCoV-ENT_nsp10_12 VCQVCGFWRDGSCSCVSTDT---TVQ NC_001846_MHV_MHV-A59_nsp10_1316 VCQVCGFWRDGSCSCVGTGS---QFQ NC_007732_PHEV_VW572_nsp10_12907 VCQVCGFWRDGSCSCVSTDT---TVQ EF424621_AntelopeCoV_US/OH1/2003 VCQVCGFWRDGSCSCVSTDT---TVQ EF424622_GiCoV_US/OH3-TC/2006_ns VCQVCGFWRDGSCSCVSTDT---TVQ NC_004718_SARS-human_Tor2_nsp10_ VCTVCGMWKGYGCSCDQLREP--LMQ AY304488_SARS-civet_SZ16_nsp10_1 VCTVCGMWKGYGCSCDQLREP--LMQ NC_009694_SARS-bat_HKU3-1_nsp10_ VCTVCGMWKGYGCSCDQLREP--MMQ AY545919_SARS-badger_CFB/SZ/94/0 VCTVCGMWKGYGCSCDQLREP--LMQ NC_009019_Bat-CoV-HKU4_B04f PCNVCQYWVGYGCNCDALRNN-TVPQ NC_009020_Bat-CoV-HKU5_LMH3f PCNVCQFWIGHGCNCDALRGT-TIPQ NC_009021_Bat-CoV-HKU9_BF_005I VCAVCNMWQGYGCPCSSLREI--NLQ NC_001451_IBV_Beaudette_nsp10_11 VCTVCQCWIGYGCQCDSLRQPKSSVQ AY646283_IBV-partridge_Partridge VCTVCQCWIGHGCQCDALRQPKPAIQ AY641576_IBV-peafowl_Peafowl/GD/ VCTVCQCWIGYGCQCDSLRQPKPSVQ * ** * .* * *